Publications 2002-2014 :

La plupart des derniers articles sont réalisés en partie grace à vos dons et notre Association est remerciée

2017

Boisgerault, N., Gregoire, M., Fonteneau, J. F. Viral cancer therapies: are they ready for combination with other immunotherapies? Future Oncol, 2017, 13(18):1569-1571.

Pouliquen, D. L., Nawrocki-Raby, B., Nader, J., Blandin, S., Robard, M., Birembaut, P., Gregoire, M. Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. Oncotarget, 2017. 10.18632/oncotarget.15744.

Achard, C., Guillerme, J. B., Bruni, D., Boisgerault, N., Combredet, C., Tangy, F., Jouvenet, N., Gregoire, M., Fonteneau, J. F. Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells. OncoImmunology, 6(1), e1261240, 2017.

Allagui, F., Achard, C., Panterne, C., Combredet, C., Labarriere, N., Dreno, B., Elgaaied, A. B., Pouliquen, D., Tangy, F., Fonteneau, J. F., Gregoire, M., Boisgerault, N. Modulation of the Type I Interferon Response Defines the Sensitivity of Human Melanoma Cells to Oncolytic Measles Virus. Current gene therapy, Jan 2017.

2016

Chene, A. L., d'Almeida, S., Blondy, T., Tabiasco, J., Deshayes, S., Fonteneau, J. F., Cellerin, L., Delneste, Y., Gregoire, M., Blanquart, C. Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages. J. Thorac. Oncol., 11(10), 1765-1773, 2016.

El Bahhaj, F., Denis, I., Pichavant, L., Delatouche, R., Collette, F., Linot, C., Pouliquen, D., Gregoire, M., Heroguez, V. Blanquart, C., Bertrand, P., Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy. Theranostics, 6(6), 795-807, 2016.

Roulois, D., Deshayes, S., Guilly, M. N., Nader, J. S., Liddell, C., Robard, M., Hulin, P., Ouacher, A., Le Martelot, V. Fonteneau, J. F., Gregoire, M., Blanquart, C., Pouliquen, D. L. Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine. Oncotarget  , 7(23), 34664-34687, 2016.


2015

Denis I, El Bahhaj F, Collette F, Delatouche R, Gueugnon F, Pouliquen D, Pichavant L, Héroguez V, Grégoire M, Bertrand P, Blanquart C. 2015. Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery. Eur J Med Chem. 95:369-76.

 C Achard, N Boisgerault, T Delaunay, F Tangy, M Grégoire, and JF Fonteneau. 2015. Induction of immunogenic tumor cell death by attenuated oncolytic measles virus. J clin cell immunol. 2015

 
 2014

Denis, I., Cellerin, L., Gregoire, M., Blanquart. Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma. Oncotarget, 10/2014; ·

Fatima El Bahhaj, Jérôme Désiré, Christophe Blanquart, Nadine Martinet, Vincent Zwick, Claudia Simões-Pires, Muriel Cuendet, Marc Grégoire, Philippe Bertrand. Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities. Tetrahedron 10/2014; ·

Iza Denis, Fatima El Bahhaj, Floraine Collette, Régis Delatouche, Fabien Gueugnon, Daniel Pouliquen, Loic Pichavant, Valérie Héroguez, Marc Gregoire, Philippe Bertrand, Christophe Blanquart. Vorinostat-Polymer Conjugate Nanoparticles for Acid-Responsive Delivery and Passive Tumor Targeting. Biomacromolecules 10/2014; ·

C.Vincent Zwick, Alkiviadis-Orfefs Chatzivasileiou, Nathalie Deschamps, Marina Roussaki, Claudia A. Simões-Pires, Alessandra Nurisso, Iza Denis,  Christophe Blanquart, Nadine Martinet, Pierre-Alain Carrupt, Anastasia Detsi, and Muriel Cuendet. Aurones as histone deacetylase inhibitors: identification of key features. Bioorganic & Medicinal Chemistry Letters. 2014. (in press)

Michael. S. Christodoulou, Adeline Thomas, Stéphane Poulain, Melita Vidakovic, Maija.lahtela-kakkonen, Daumantas Matulis, Philippe Bertrand, Eva Bartova, Christophe Blanquart, Emmanuel Mikros, Nikolas Fokialakis, Daniele Passarella, Rachid Benhida and Nadine Martinet. Can we use the epigenetic bioactivity of phytochemicals to promote healthy ageing? MedChemComm. 2014 (in press).

Gueugnon F, Cartron PF, Charrier C, Bertrand Ph, Fonteneau JF, Gregoire M and Blanquart Ch. New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells. Oncotarget, 5(12):4504-4515, 2014.

Curcumin. Synthesis, Emerging Role in Pain Management and Health Implications. D. L. Pouliquen (ed.), Nova Science Publishers, Inc., New York, NY, USA, 2014, ISBN: 978-1-63321-319-7, 517pp.

Pouliquen DL, Nawrocki-Raby B, Ouacher A, Deleine C, Blandin S, Robard M, Birembaut P, Grégoire M. New prospects with curcumin in the treatment of mesothelioma: lessons from an orthotopic rat tumor model. In: Curcumin. Synthesis, Emerging Role in Pain Management and Health Implications. D. L. Pouliquen (ed.), Nova Science Publishers, Inc., New York, NY, USA, 2014, ISBN : 978-1-63321-319-7, pp 435-455.


2013

Guillerme, J.B.; Gregoire, M.; Tangy, F.; Fonteneau, J.F., Antitumor virotherapy by attenuated measles virus (mv). Biology 2:587-602, 2013.

Fonteneau, J.-F., Guillerme, J.-B., Tangy, F. and Grégoire, M. Attenuated measles virus used as an oncolytic virus activates myeloid and plasmacytoid dendritic cells. OncoImmunology, 2(5)  May 2013. eLocation ID: e24212

Guillerme, J.B., Boisgerault, N., Roulois, D., Ménager, J., Combredet, Ch., Tangy, F., Fonteneau, J.F., and Gregoire, M. Measles virus-vaccine infected tumor cells induce tumor antigen cross-presentation by human plasmacytoid dendritic cells. Clinical Cancer Research,19:1147-1158, 2013.

Boisgerault, N., Guillerme, J.-B., Pouliquen, D., Mesel-Lemoine, M., Combredet, Ch., Achard, C., Fonteneau, J.-F., Tangy F. and Grégoire M. Natural oncolytic activity of live-attenuated measles virus against human lung and colorectal adenocarcinomas. J. Biomed Biotech. Special Issue " Oncolytic Virus-Based Cancer Gene Therapy", Volume 2013 (2013), http://dx.doi.org/10.1155/2013/387362.

Delatouche, R., I. Denis, M. Grinda, F. El Bahhaj, E. Baucher, F. Collette, V. Heroguez, M. Grégoire, Ch. Blanquart*, Ph. Bertrand*. Design of pH responsive clickable prodrugs applied to histone deacetylases inhibitors: a new strategy for anticancer therapy. European Journal of Pharmaceutics and Biopharmaceutics. (in press. DOI:10.1016/j.ejpb.2013.03.006)

Gueugnon F, Denis I, Pouliquen D, Collette F, Delatouche R, Héroguez V, Grégoire M, Bertrand P, Blanquart C.Nanoparticles produced by ring-opening metathesis polymerization using norbornenyl-poly(ethylene oxide) as a ligand-free generic platform for highly selective in vivo tumor targeting. Biomacromolecules. 2013 Jul 8;14(7).

Floraine Collette, Régis Delatouche, Christophe Blanquart, Fabien Gueugnon, Marc Grégoire, Philippe Bertrand, Valérie Héroguez. An easy and effective method to produce functionalized nanoparticles for cellular uptake. Journal of Polymer Science Part A: Polymer Chemistry. 51:176-189, 2013

 Cartron, P.F., Blanquart, Ch., Hervouet, E., Gregoire, M. and Vallette F.M. HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression. Molecular Oncology. 7(3): 452 – 463, 2013.

 Roulois D, Grégoire M, and Fonteneau JF. MUC1-specific cytotoxic T lymphocytes in cancer therapy: induction and challenge. BioMed Research International. DOI:10.1155/2013/871936

 Grégoire M. Immunothérapie du mésothéliome. Revue des Maladies Respiratoires Actualités. 5:221-224, 2013.

  2012

 Delphine Coulais,  Clarisse Panterne, Jean-François Fonteneau and Marc Grégoire. Purification of Circulating Plasmacytoid Dendritic Cells Using Counterflow Centrifugal Elutriation and Immunomagnetic Beads. Cytotherapy, (on line) 2012. DOI: 10.3109/14653249.2012.689129

 Blanquart C, Gueugnon F, Nguyen JM,  Roulois D, Cellerin L, Sagan Ch, Perigaud Ch, Scherpereel A,  and Gregoire M. The combination of CCL2, LGALS3 and soluble mesothelin related peptide biomarkers improves the diagnosis of Mesothelioma in pleural effusions. J. Thor. Oncol., 7(5):883-889. 2012.

 David Roulois, Christophe Blanquart, Clarisse Panterne, Fabien Gueugnon,  Marc Grégoire and Jean-François Fonteneau. Downregulation of MUC1 expression and its recognition by CD8+ T cells on the surface of malignant pleural mesothelioma cells treated with HDACi. Eur. J. Immunol., 2012, DOI: 10.1002/eji.201141800.

 Thomas Simon, Séverine Tanguy-Royer, Pierre-Joseph Royer, Nicolas Boisgerault, Jihane Frikeche, Jean-François Fonteneau and Marc Grégoire. Human dendritic cells sequentially matured with CD4+ T cells as a secondary signal favor CTL and long-term memory T cell responses. Biological Research, 45 (1):33-43, 2012.

Pouliquen DL, Grégoire M. Phytochemicals in cancer research: a review of their biological activities and anticancer potentials in preclinical and clinical studies. In: Phytochemicals: occurrence in nature, health effects and antioxidant properties, Kuang Haixue (ed.), Nova Science Publishers Inc., New York, NY, USA, 2012 (in press),

 Pouliquen DL, Grégoire M. Overview of translational studies with the rat in cancer research: a historical introduction. Chapter 1, 32 pages, In: The rat in cancer research: a crucial tool for all aspects of translational studies, Daniel L. Pouliquen (ed.), esearch Signpost, Trivandrum, Kerala, India, 2012 (in press), ISBN: 978-81-308-0485-9.

  2011

Fabien Gueugnon, Sabrina Leclercq, Christophe Blanquart, Christine Sagan, Laurent Cellerin, Martine Padieu, Christian Perigaud, Arnaud Scherpereel and Marc Gregoire. Identification of novel markers for the diagnosis of malignant pleural mesothelioma. Am. J. Pathol. 178(3):1033-42, 2011.

 Sabrina Leclercq§, Fabien Gueugnon§, Benoit Boutin, Flora Guillot, Christophe Blanquart, Anne Rogel, Martine Padieu, Daniel Pouliquen, Jean-François Fonteneau and Marc Grégoire. 5-aza-2'-deoxycytidine/valproate combination induces CTL response against mesothelioma. Eur. Resp. J., 38: 1105-1116 Mai 2011. §Both authors contributed equally

 Christophe Blanquart, Manon François, Cedric Charrier, Philippe Bertrand and Marc Gregoire. Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. Current Cancer Drug Targets, 11 (8):919-928, 2011.

 David Roulois, Virginie Vignard, Fabien Gueugnon, Nathalie Labarrière, Marc Grégoire and Jean-François Fonteneau. Recognition of pleural mesothelioma by MUC1(950-958)/HLA-A*0201 specific CD8+ T lymphocyte. Eur. Resp. J., 38(5): 1117-1126, 2011.

 Flora Guillot, Benoit Boutin, Christophe Blanquart, Jean-François Fonteneau, Myriam Robard, Marc Grégoire and Daniel Pouliquen. Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth. Vaccine, 29 (33):5534-5543, 2011.

 Delneste, Y. Gregoire, M., Cuturi, M. C., Anegon, I. Yin Yang of immunoregulation in organ transplantation and cancer. Immunotherapy 3(4supp) ; 1-3, 2011.

 Frikeche, J., Clavert, A., Delaunay, J., Brissot, E., Gregoire, M., Gaugler, B., Mohty, M. Impact of the hypomethylating agent 5-azacytidine on dendritic cells function. Exp. Hematol. 39(11):1056-63, 2011.

 2010

Boisgerault N, Tangy F and Grégoire M. New perspectives in cancer virotherapy: bringing the immune system into play. Immunotherapy, 2010, march 2(2), 185-199, 2010.

 Grégoire M. What's the place of immunotherapy in malignant mesothelioma treatment ? Cell Adhesion and Migration, Vol 4, n°1, 153-161, 2010.

 Grégoire M. A near future for curative vaccine in mesothelioma. Expert Review of Respiratory Medicine 4(3), 311-314, 2010.

 2009

Remy, S., Blancou, P., Tesson, L., Tardif, V., Brion, R. ,Royer, P. J., Motterlini, R., Foresti, R., Painchaut, Pogu, S., Gregoire, M., Bach, J. M., Anegon, I., Chauveau, C. Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity, J Immunol., 182(4):1867-1884, 2009.

 Grigoriu B., Chahine B., Zerimech F., Grégoire M., Balduyck, Copin M.C., Devos P, Lassalle P, Scherpereel A.(2009)  Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma.  Clin Biochem, 42 (10-11), 1046-1050, 2009.

 Thomas Simon, Jean-François Fonteneau, Marc Grégoire (2009)  Dendritic cell preparation for immunotherapeutic interventions   Immunotherapy 1: 2. 289-302, 2009.  

 2008

Bogdan-Dragos Grigoriu, Marc Grégoire, Bachar Chachine and Arnaud Scherpereel. Nouveaux marqueurs diagnostiques du mésothéliome pleural malin (New diagnostic markers for malignant pleural mesothelioma). Bull Cancer 95 (2) : 1-8, 2008.

 Carole Sapede, Anne Gauvrit, Isabelle Barbieux, Martine Padieu, Laurent Cellerin, Christine Sagan, Arnaud Scherpereel, Gérard Dabouis and Marc Grégoire. Aberrant splicing and protease involvement in mesothelin release from epithelioid mesothelioma cells. Cancer Science 99 (3), 590-594, 2008.

 Royer, P. J., Bougras, G., Ebstein, F., Leveque, L., Tanguy-Royer, S., Simon, T., Juge-Morineau, N. Chevallier, P., Harousseau, J. L., Gregoire, M. Efficient monocyte-derived dendritic cell generation in atients with acute myeloid leukemia after chemotherapy treatment: Application to active immunotherapy. Exp. Hematol. ; 36 (3) : 329-339, 2008.

 A. Gauvrit, S. Brandler, C. Sapede-Peroz, N. Boisgerault, F. Tangy and M. Gregoire. Measles virus induces Oncolysis of Mesothelioma Cells and allows DC to Cross-Prime Tumor-specific CD8 Response. Cancer Research 68 (12),  4882-4892, 2008.

 Pichard, V., Royer, P. J., Richou, C., Cauchin, E., Goebes, K., Gaignerie, A., Masliah, C. Gournay, J., Gregoire, M., Ferry, N. Detection, Isolation, and Characterization of alpha-fetoprotein-specific T Cell Populations and Clones Using MHC Class I Multimer Magnetic Sorting. J Immunother.31 (3), 246-253; 2008.  

 L. Bertaux, M.-N. Mevelec, S. Dion, V. Suraud, M. Grégoire, P. Berthon and I. Dimier-Poisson. Apoptotic pulsed dendritic cells induce a protective immune response against Toxoplasma gondii. Parasite Immunology 30, 620-629, 2008.

 2007

Gregoire Marc et Ebstein Frédéric. L’immunothérapie dans le mésothéliome malin : perspectives thérapeutiques. Bull Cancer 94 (1) : 1-9, 2007.

 Grigoriu Bogdan-Dragos, Arnaud Scherpereel,Patrick Devos, Bachar Chahine,Marc Letourneux, Pierre Lebailly, Marc Gregoire, Henri Porte, Marie-Christine Copin, and Philippe Lassalle. Utility of Osteopontin and Serum Mesothelin in Malignant Pleural Mesothelioma Diagnosis and Prognosis Assessment, Clin Cancer Res, 13(10), 2928-2935, 2007.

 Marcelo Hill, Séverine Tanguy-Royer, Christine Chauveau, Kashif Asghar, Pierre Royer,  Frédéric Lavainne, Séverine Rémy, Régis Brion, François-Xavier Hubert, Michèle Heslan, Marie Rimbert, John R Moffett,  Régis Josien, Marc Grégoire and Ignacio Anegon. Indoleamine 2,3-dioxygenase expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells . Eur. J. Immunol. 37:3054-3062, 2007

 Gilles Vassal, et al. LEEM Recherche. Recherche translationnelle et plan cancer. Bull. Cancer 2007 ; 94 (12) : 1107-1111.

 2006

Arnaud Scherpereel, Bogdan D Grigoriu, Massimo Conti, Thomas Gey, Marc Gregoire, Marie-Christine Copin, Patrick Devos, Bachar Chahine, Henri Porte, and Philippe Lassalle. Soluble Mesothelin-related Protein in the Diagnosis of Malignant Pleural Mesothelioma. Am. J. Respir. Crit. Care Med. 173:1155-1160, 2006

 Royer Pierre-Joseph, Tanguy-Royer Severine, Ebstein Frederic, Sapede Carole, Simon Thomas, Barbieux Isabelle, Oger Romain, and Gregoire Marc. Culture medium and protein supplementation in the generation and maturation of dendritic cells. Scand. J. Imm. 63 (6), 401-409, 2006.

 2005

D. Carbonelle*, F. Ebstein*, C. Rabu, J.Y. Petit, M. Grégoire and F. Lang. A new carboxamide compound exerts immunosuppressive activity by inhibiting dendritic cell maturation. Eur. J. Immunol. 35 (2), 546-556, 2005 * Both authors contributed equally

 C. Chauveau, S. Rémy* , P. J. Royer* , M. Hill, S. Tanguy-Royer, F.-X. Hubert, L. Tesson, R. Brion, G. Beriou, M. Gregoire, R. Josien, M. C. Cuturi and I. Anegon. Heme oxygenase-1 expression inhibits dendritic cell maturation and pro-inflammatory function but conserves IL-10 expression. Blood 106: 1694 – 1702, 2005. * Both authors contributed equally

 D. McIlroy, S. Tanguy-Royer, N. Le Meur, I. Guisle, P.-J. Royer, J. Léger, K. Meflah, and M. Grégoire. Profiling dendritic cell maturation with dedicated micro-arrays. J. Leuk. Biol. 78 (3), 794-803, 2005

 2004

D. Massé, F. Ebstein, G. Bougras, J. Harb, K. Meflah and M. Grégoire. Increased expression of inducible HSP70 within apoptotic cells is correlated with their efficacy for antitumor vaccine therapy. Int. J. Cancer 111 (4), 575-580, 2004

 Faure, O. Graff-Dubois, S., Bretaudeau, L., Derre, L., Gross, D. A., Alves, P. M., Cornet, S., Duffour, M. T., Chouaib, S., Miconnet, I., Gregoire, M., Jotereau, F., Lemonnier, F. A., bastado, J. P., Kosmatopoulos, K.  Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA-A*0201-restricted epitopes. Int J Cancer, 108, 863-870, 2004

 Ebstein F, Sapede C, Royer P.-J., Marcq M., Ligeza-Poisson C., Barbieux I., Cellerin L., Dabouis G. and Grégoire M. Cytotoxic T cell responses against mesothelioma by apoptotic cell-pulsed dendritic cells. Am. J. Respir. Crit. Care Med., 169 (12), 1322-1330, 2004.

Bougras, G., P.F. Cartron, F. Gautier, S. Martin, MT LeCabellec, K. Meflah, M. Grégoire, F. Valette. Opposite role of Bax and BCL- 2 in the anti-tumoral responses of the immune system. BMC Cancer, 4, 54, 2004.

 2003

Grégoire, M., Ligeza-Poisson, C., Juge-Morineau, N. and Spisek, R. Anti-cancer therapy using dendritic cells and apoptotic tumour cells : pre-clinical data in human mesothelioma and acute myeloid leukemia. Vaccine, 21 (7-8),  791-794, 2003

 Spisek, R., Bougras, G., Ebstein, F, Masse, D., Meflah, K, McIlroy, D., and Grégoire M. Transient exposure of dendritic cells to maturation stimuli is sufficient to induce complete phenotypic maturation while preserving their capacity to respond to subsequent restimulation. Cancer Immunol. Immunoth., 52, 445-454, 2003

 McIlroy, D., Grégoire, M. Optimizing dendritic cell-based anticancer immunotherapy : maturation state does have clinical impact. Cancer Immunol. Immunoth., 52 (10), 583-591, 2003

 2002

Massé, D., Voisine,C., Henry, F., Cordel, S., Barbieux, I., Josien, R., Meflah, K., Grégoire, M., Lieubeau, B.  Increased vaccination efficiency with apoptotic cells by silica-induced dendritic-like cells. Cancer Research 32(4), 1050-1056, 2002.

 Oliver L., Cordel, S., Barbieux, I., Le Cabellec, M.T., Meflah, K., Grégoire, M., and Valette, F.M. Resistance to apoptosis in increased during metastatic dissemination of colon cancer. Clinical and Experimental Metastasis (2002) 19, 175-180. 

 Spisek, R., Chevallier, P., Morineau, N., Milpied, N., Avet-Loiseau, H., Harousseau, J.L., Meflah, K., Gregoire, M. Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of non-leukemic origin. Cancer Research (2002) 62, 2861-2868.

 Labarrière, N., Bretaudeau, L., Bodinier, M., Gervois, N., Bougras, G., Diez, E., Lang, F., Gregoire, M., Jotereau, F. Priming and cross priming of naive CD8 T lymphocytes against the melanoma specific antigen NA17-A, using dendritic cells loaded with peptides and with melanoma derived apoptotic bodies. Int. J. Cancer., (2002) 101, 280-286.

 F. Jotereau, N. Labarrière, N. Gervois, L. Bretaudeau and M. Grégoire. Cellules dendritiques et mélanome. Oncologie, 3 : 371-377, 2002.